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1

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases

Tsai, Shiou-Chuan (Sheryl)

Journal:

Annual Review of Biochemistry

Year:

2018

Language:

english

File:

PDF, 4.45 MB

english, 2018

2

Stereospecific Ligand Substitutions in Manganese(I) Complexes

Shiou-Chuan Tsai, Hsin-Ell Wang, Chi-Tsuan Huang, Lih-Ming Yiin, Shiuh-Tzung Liu

Journal:

European Journal of Inorganic Chemistry

Year:

1995

Language:

english

File:

PDF, 538 KB

english, 1995

3

A Fine Balancing Act of Type III Polyketide Synthase

Shiou-Chuan Tsai

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 48 KB

english, 2004

4

De Novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note

Shiou-Chuan Tsai, Judith P. Klinman

Journal:

Bioorganic Chemistry

Year:

2003

Language:

english

File:

PDF, 277 KB

english, 2003

5

Fatty acid biosynthesis in actinomycetes

Gabriela Gago, Lautaro Diacovich, Ana Arabolaza, Shiou-Chuan Tsai, Hugo Gramajo

Journal:

FEMS Microbiology Reviews

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

6

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Crawford, Jason M., Korman, Tyler P., Labonte, Jason W., Vagstad, Anna L., Hill, Eric A., Kamari-Bidkorpeh, Oliver, Tsai, Shiou-Chuan, Townsend, Craig A.

Journal:

Year:

2009

Language:

english

File:

PDF, 782 KB

english, 2009

7

Crystal Structure of the Priming β-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway

Hu Pan, Shiou-chuan Tsai, Eric S. Meadows, Larry J.W. Miercke, Adrian T. Keatinge-Clay, Joe O'Connell, Chaitan Khosla, Robert M. Stroud

Journal:

Year:

2002

Language:

english

File:

PDF, 2.00 MB

english, 2002

8

Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase

Adrian T. Keatinge-Clay, Anang A. Shelat, David F. Savage, Shiou-Chuan Tsai, Larry J.W. Miercke, Joseph D. O'Connell III, Chaitan Khosla, Robert M. Stroud

Journal:

Year:

2003

Language:

english

File:

PDF, 654 KB

english, 2003

9

Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis

Kenji Watanabe, Chaitan Khosla, Robert M. Stroud, Shiou-Chuan Tsai

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.49 MB

english, 2003

10

Babysitting Flavin for Biosynthesis

Shiou-Chuan Tsai

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 260 KB

english, 2012

11

2.6 Å X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase,

Smith, Peter, Zhou, Bingsen, Ho, Nam, Yuan, Yate-Ching, Su, Leila, Tsai, Shiou-Chuan, Yen, Yun

Journal:

Year:

2009

Language:

english

File:

PDF, 4.41 MB

english, 2009

12

Crystal Structure of the β -Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity †,‡

Diacovich, Lautaro, Mitchell, Deborah Lynn, Pham, Huy, Gago, Gabriela, Melgar, Melrose Mendoza, Khosla, Chaitan, Gramajo, Hugo, Tsai, Shiou-Chuan

Journal:

Year:

2004

Language:

english

File:

PDF, 1.18 MB

english, 2004

13

Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI

Lee, Ming-Yue, Ames, Brian D., Tsai, Shiou-Chuan

Journal:

Year:

2012

Language:

english

File:

PDF, 2.22 MB

english, 2012

14

Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities

Javidpour, Pouya, Das, Abhirup, Khosla, Chaitan, Tsai, Shiou-Chuan

Journal:

Year:

2011

Language:

english

File:

PDF, 7.46 MB

english, 2011

15

Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase

Javidpour, Pouya, Korman, Tyler Paz, Shakya, Gaurav, Tsai, Shiou-Chuan

Journal:

Year:

2011

Language:

english

File:

PDF, 4.15 MB

english, 2011

16

Probing the Selectivity and Protein⋅Protein Interactions of a Nonreducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Bruegger, Joel, Haushalter, Bob, Vagstad, Anna, Shakya, Gaurav, Mih, Nathan, Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 2.75 MB

english, 2013

17

The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase

Javidpour, Pouya, Bruegger, Joel, Srithahan, Supawadee, Korman, Tyler P., Crump, Matthew P., Crosby, John, Burkart, Michael D., Tsai, Shiou-Chuan

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 1.72 MB

english, 2013

18

Probing the Selectivity and Protein⋅Protein Interactions of a Nonreducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Bruegger, Joel, Haushalter, Robert W., Vagstad, Anna L., Beld, Joris, Shakya, Gaurav, Mih, Nathan, Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 97 KB

english, 2014

19

Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases †,‡

Tsai, Shiou-Chuan, Lu, Hongxiang, Cane, David E., Khosla, Chaitan, Stroud, Robert M.

Journal:

Year:

2002

Language:

english

File:

PDF, 1.12 MB

english, 2002

20

Polyketide Chain Length Control by Chain Length Factor

Tang, Yi, Tsai, Shiou-Chuan, Khosla, Chaitan

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 92 KB

english, 2003

21

Structure and Mutagenic Conversion of E 1 Dehydrase: At the Crossroads of Dehydration, Amino Transfer, and Epimerization †‡

Smith, Peter, Szu, Ping-Hui, Bui, Cynthia, Liu, Hung-wen, Tsai, Shiou-Chuan

Journal:

Year:

2008

Language:

english

File:

PDF, 10.07 MB

english, 2008

22

Inhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase †,‡

Korman, Tyler Paz, Tan, Yu-Hong, Wong, Justin, Luo, Ray, Tsai, Shiou-Chuan

Journal:

Year:

2008

Language:

english

File:

PDF, 608 KB

english, 2008

23

Structural and Biochemical Characterization of ZhuI Aromatase/Cyclase from the R1128 Polyketide Pathway

Ames, Brian D., Lee, Ming-Yue, Moody, Colleen, Zhang, Wenjun, Tang, Yi, Tsai, Shiou-Chuan

Journal:

Year:

2011

Language:

english

File:

PDF, 7.15 MB

english, 2011

24

Influence Relevance Voting: An Accurate And Interpretable Virtual High Throughput Screening Method

Swamidass, S. Joshua, Azencott, Chloé-Agathe, Lin, Ting-Wan, Gramajo, Hugo, Tsai, Shiou-Chuan, Baldi, Pierre

Journal:

Journal of Chemical Information and Modeling

Year:

2009

Language:

english

File:

PDF, 983 KB

english, 2009

25

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

Khakshoor, Omid, Lin, Aaron J., Korman, Tyler P., Sawaya, Michael R., Tsai, Shiou-Chuan, Eisenberg, David, Nowick, James S.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 3.91 MB

english, 2010

26

Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit of Streptomyces coelicolor ,

Arabolaza, Ana, Shillito, Mary Elizabeth, Lin, Ting-Wan, Diacovich, Lautaro, Melgar, Melrose, Pham, Huy, Amick, Deborah, Gramajo, Hugo, Tsai, Shiou-Chuan

Journal:

Year:

2010

Language:

english

File:

PDF, 4.10 MB

english, 2010

27

Probes of Hydrogen Tunneling with Horse Liver Alcohol Dehydrogenase at Subzero Temperatures †

Tsai, Shiou-chuan, Klinman, Judith P.

Journal:

Year:

2001

Language:

english

File:

PDF, 103 KB

english, 2001

28

Expression, Site-Directed Mutagenesis, and Steady State Kinetic Analysis of the Terminal Thioesterase Domain of the Methymycin/Picromycin Polyketide Synthase †

Lu, Hongxiang, Tsai, Shiou-Chuan, Khosla, Chaitan, Cane, David E.

Journal:

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

29

Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity ‡

Korman, Tyler Paz, Hill, Jason Anthony, Vu, Thanh Nhat, Tsai, Shiou-Chuan

Journal:

Year:

2004

Language:

english

File:

PDF, 1.33 MB

english, 2004

30

The type I fatty acid and polyketide synthases: a tale of two megasynthases

Smith, Stuart, Tsai, Shiou-Chuan

Journal:

Natural Product Reports

Year:

2007

Language:

english

File:

PDF, 1.80 MB

english, 2007

31

Editorial: Fungal natural products themed issue

Challis, Gregory L., Tsai, Shiou-Chuan

Journal:

Natural Product Reports

Year:

2014

Language:

english

File:

PDF, 143 KB

english, 2014

32

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Tyler Paz Korman, Jason M. Crawford, Jason W. Labonte, Adam G. Newman, Justin Wong, Craig A. Townsend, Shiou-Chuan Tsai and Stephen J. Benkovic

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.57 MB

english, 2010

33

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols

Barajas, Jesus F., Phelan, Ryan M., Schaub, Andrew J., Kliewer, Jaclyn T., Kelly, Peter J., Jackson, David R., Luo, Ray, Keasling, Jay D., Tsai, Shiou-Chuan

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 3.66 MB

english, 2015

34

Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis

Jackson, David R., Tu, Stephanie S., Nguyen, MyChi, Barajas, Jesus F., Schaub, Andrew J., Krug, Daniel, Pistorius, Dominik, Luo, Ray, Müller, Rolf, Tsai, Shiou-Chuan

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.68 MB

english, 2015

35

Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA

Finzel, Kara, Nguyen, Chi, Jackson, David R., Gupta, Aarushi, Tsai, Shiou-Chuan, Burkart, Michael D.

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

36

Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE

Jackson, David, Yu, Xia, Wang, Guojun, Patel, Avinash, Barajas, Jesus, Sasaki, Eita, Metsa-Ketala, Mikko, Liu, Hung-wen, Rohr, Jürgen, Tsai, Shiou-Chuan (Sheryl)

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.37 MB

english, 2016

37

The Alga Ochromonas danica Produces Bromosulfolipids

White, Alexander R., Duggan, Brendan M., Tsai, Shiou-Chuan, Vanderwal, Christopher D.

Journal:

Organic Letters

Year:

2016

Language:

english

File:

PDF, 553 KB

english, 2016

38

An unusual intramolecular trans-amidation

Rivera, Heriberto, Dhar, Sachin, La Clair, James J., Tsai, Shiou-Chuan, Burkart, Michael D.

Journal:

Year:

2016

Language:

english

File:

PDF, 832 KB

english, 2016

39

Synthesis of 2,6-Disubstituted Fluorenones

Tsai, Shiou-Chuan, Liu, Shiuh-Tzung

Journal:

Journal of the Chinese Chemical Society

Year:

1991

Language:

english

File:

PDF, 768 KB

english, 1991

40

Photochemical Substitution of fac- Tricarbonyl[P,P′,S- (2,2-Bis (diphenylphosphinomethyl)-1-Phenylthiopropane) ]manganese(I) Hexafluorophosphate by Diphenylphosphine

Tsai, Shiou-Chuan, Cheng, Ming-Chu, Peng, Shic-Ming, Liu, Shiuh-Tzung

Journal:

Journal of the Chinese Chemical Society

Year:

1993

Language:

english

File:

PDF, 350 KB

english, 1993

41

Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis

Valentic, Timothy R, Jackson, David R., Brady, Sean F., Tsai, Shiou-Chuan (Sheryl)

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

42

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan, Challis, Gregory L.

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

43

A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes

White, Alexander, Kozlowski, Ryan, Tsai, Shiou-Chuan, Vanderwal, Christopher D.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

44

A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes

White, Alexander R., Kozlowski, Ryan A., Tsai, Shiou-Chuan, Vanderwal, Christopher D.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 757 KB

english, 2017

45

An Oxetane-based Polyketide Surrogate to Probe Substrate Binding in a Polyketide Synthase

Ellis, Bryan Daniel, Milligan, Jacob C., White, Alexander R., Duong, Vy, Altman, Pilar X., Mohammed, Lina, Crump, Matthew P., Crosby, John, Luo, Ray, Vanderwal, Christopher D., Tsai, Shiou-Chuan

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 591 KB

english, 2018

46

ChemInform Abstract: An Unusual Intramolecular trans-Amidation.

Rivera, Heriberto Jr., Dhar, Sachin, La Clair, James J., Tsai, Shiou-Chuan, Burkart, Michael D.

Journal:

Year:

2016

File:

PDF, 17 KB

2016

47

Molecular Basis for Polyketide KetoreductaseâSubstrate Interactions

Zhao, Shiji, Ni, Fanglue, Qiu, Tianyin, Wolff, Jacob T., Tsai, Shiou-Chuan, Luo, Ray

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 5.17 MB

2020